An incremental increase in the complexity of peptides bound to class II MHC changes the diversity of positively selected alpha beta TCRs.

An Incremental Increase in the Complexity of Peptides Bound to Class II MHC Changes the Diversity of Positively Selected ab TCRs

Effects of Altitude and Soil Properties on Alpha and Beta Diversity in Plour Rangelands of Mazandaran

Biodiversity is one of the important aspects of natursal systems which supports ecosystem functions. Therefore, the preservation of biodiversity is necessary for human well-being. The curreny study aimed to investigate changes of alpha and beta diversity and its components along the elevation gradient of five classes and to evaluate the effects of physical and chemical characteristics of soil o...

In the normal repertoire of CD4+ T cells, a single class II MHC/peptide complex positively selects TCRs with various antigen specificities.

In the thymus, immature T cells are positively and negatively selected by multiple interactions between their Ag receptors (TCRs) and self MHC/peptide complexes expressed on thymic stromal cells. Here we show that in the milieu of negative selection on physiological self class II MHC/peptide complexes (Abwt), a single class II/peptide complex AbEp52-68 positively selects a number of TCRs with v...

H-2-restricted cytolytic T lymphocytes specific for HLA display T cell receptors of limited diversity

We previously showed that H-2Kd-restricted cytotoxic T lymphocyte (CTL) clones specific for a single nonapeptide derived from the Plasmodium berghei circumsporozoite (PbCS) protein displayed T cell receptors (TCRs) of highly diverse primary structure. We have now analyzed the TCR repertoire of CTLs that recognize a peptide derived from the human class I major histocompatibility complex (MHC) mo...

Mature CD4+ T cells perceive a positively selecting class II MHC/peptide complex in the periphery.

A repertoire of TCRs is selected in the thymus by interactions with MHC bound to self-derived peptides. Whether self peptides bound to MHC influence the survival of mature T cells in the periphery remains enigmatic. In this study, we show that the number of naive CD4+ T cells that developed in mice with class II MHC bound with endogenous peptides (Abwt) diminished when transferred into mice wit...